Rift Valley fever: A tropical emerging viral zoonosis of public health concern


  • Mahendra Pal Narayan Consultancy on Veterinary Public Health and Microbiology- Anand-388001, Gujarat, India
  • Kirubel Paulos Gutama Adaba Woreda livestock and fishery resource, development office, Adaba, West Arsi, Ethiopia
  • Dinaol Tolawak Ilu Galan Woreda livestock and fishery Resource development office, Illu Galan, West Shoa, Ethiopia


Epidemiology, Mosquitoes, Public health Risk factors, Rift Valley fever, Rift valley, viral zoonosis


Rift Valley fever is an emerging viral disease that has been reported from several countries including Kenya, Saudi Arabia, Somalia, Sudan, Tanzania and Yemen. The most commonly affected animals are domesticated ruminants, which may act as significant virus amplifiers. The disease is most commonly found in Sub-Saharan Africa, with occasional outbreaks in other parts of the world. The virus is disseminated by mosquito vectors and by coming into touch with the tissue of the infected animals. Disease outbreaks are more likely to develop when there is a lot of rain, which raises the mosquito populations. The age and species of the animal determine the host's susceptibility. Human infection can be spread by the consumption or handling of sick animal products, interaction with livestock as herders and the handling of aborted fetuses, milking, skinning, butchering, sleeping with animals, touching the blood, and animal care after birth. Flooding concentrates animals and people in dryland areas, which increase the risk of virus transmission. Animals have a much greater fatality rate than humans. Rift Valley disease causes almost all pregnant heifers to abort their fetuses. In humans, the virus can cause a range of symptoms. It usually manifests as a mild condition with symptoms such as fever, headache, muscle pains, and liver abnormalities. Only about 1% of persons who contract the disease die as a result of it. There is no specific treatment for Rift Valley fever. Vaccinating animals against the disease is one method of disease prevention. This must be done before an outbreak begins, as doing so during one could worsen the situation. Stopping animal movement, as well as reducing mosquito populations and preventing bites, may be advantageous during an outbreak. Vaccinations for humans are currently unavailable. To summarize, Rift Valley fever virus is a substantial developing zoonotic concern that requires systematic control and prevention.


Abdo-Salem S, Gerbier G, Bonnet P, Al-Qadasi M, Tran A and Thiry E. (2006). Descriptive and spatial epidemiology of Rift Valley fever outbreak in Yemen 2000-2001. Ann N Y Acad Sc, 8081, 240-242.

Anyangu A, Gould L, Sharif S, Nguku P, Omolo J and Mutonga D. (2010). Risk factors for severe Rift Valley fever infection in Kenya, 2007. Am J Trop Med Hyg, 83, 14-21.

Balenghien T, Cardinale E, Chevalier V, Elissa N, Failloux A, Jean J and Nipomichene TN. (2013). Towards a better understanding of Rift Valley fever epidemiology in the south-west of the Indian Ocean. Vet Res, 44, 78.

Balkhy H and Memish Z. (2003). Rift Valley fever: an uninvited zoonosis in the Arabian Peninsula. Int. J. Antimicrob. Agents, 21, 153-157.

Bird B, Ksiazek S, Nichol T and Maclachlan N. (2009). Rift Valley fever virus. J. Am. Vet. Med. Ass, 234, 883-893.

Bonnet P, Tibbo M, Workalemahu A and Gau M. (2001). Rift Valley fever and emerging threat to livestock trade and food security in the Horn of Africa. Ethiopian Society of Animal Production. Addis Ababa, Ethiopia, pp. 379-404.

Britch S, Binepal Y, Ruder M, Karithi H, Linthicum K and Anyamba J. (2013). Rift Valley fever risk map model and seroprevalence in selected wild ungulates and camels from Kenya. PLoS One, 8, 66-68.

Chevalier V. (2013). Relevance of Rift Valley fever to public health in the European Union. Clin. Microbiol. Infect, 19, 705-708.

Dar O, McIntyre S, Hogarth S and Heymann D. (2013). Rift Valley fever and a new paradigm of research and development for zoonotic disease control. Emerg. Infect. Dis, 19, 189-93.

Davies G and Martin V. (2006) Recognizing Rift Valley Fever. Vet. Ital, 42, 31-53.

Davis G, Martin V and Clarke N. (2003). Recognizing Rift Valley Fever. FAO Animal Health Manual, 17, 1-45.

Empres M. (2008). Rift Valley Fever in Eastern Africa. Trans-boundary Animal Diseases Bulletin Number 30.

Fafetine J, Neves L, Thompson P, Paweska J, Rutten V and Coetzer J. (2013). Serological evidence of Rift Valley fever virus circulation in sheep and goats in Zambe´zia Province, Mozambique. PLoS. Negl. Trop. Dis, 7, 2-6.

FAO (2005). Terrestrial Animal Health Code. Food and agricultural organization. USA Contributions to Epidemiology and Biostatics, 3, 178-190.

Grobbelaar A, Weyer J, Leman P, Kemp A, Paweska J and Swanepoel R. (2011). Molecular epidemiology of Rift Valley fever virus. Emerg. Infect. Dis, 17, 2270-2276.

Halawi A, Saasa N, Pongombo B, Kajihara M, Chambaro H and Hity M. (2019). Seroprevalence of Rift Valley fever in cattle of smallholder farmers in Kwilu Province in the Democratic Republic of Congo. Trop. Anim. Health. Prod, 51, 2619-2627.

Handlos M. (2009). Assessment of the estimated costs of past disease outbreaks in Yemen, Rain fed Agriculture and Livestock Project: International expertise service for the General Directorate of Animal Resources, Yemen. Sana’a and Vientiane, Yemen. IDA CR, 4220

Hassan O, Ahlm. C, Sang R and Evander M. (2011). The 2007 Rift Valley fever outbreak in Sudan. PLoS Negl. Trop. Dis, 5, 12-29.

Heinrich N, Saathoff E, Weller N, Clowes P, Kroidl I and Ntinginya E. (2012). High seroprevalence of Rift Valley fever and evidence for endemic circulation in Mbeya region, Tanzania, in a cross-sectional study. PLoS. Negl. Trop. Dis, 6, 15-17.

Janusz T. Paweska. (2014). Emerging Infectious Diseases. In Center for Emerging and Zoonotic Diseases, National Institute for Communicable Diseases of the National Health Laboratory Service and School of Pathology, Faculty of Medical Sciences, University of Witwatersrand, South Africa. Elsevier Inc.

Kahen C. (2005). The Merck Veterinary Manual. 9th Edn. White House Station, New Jersey, USA, 617-619.

LaBeaud A, Cross P, Getz W, Glinka A and King C. (2011a). Rift Valley fever virus infection in African buffalo (Syncerus caffer) herds in rural South Africa: evidence of interepidemic transmission. Am.J. Trop. Med. Hyg, 84, 641-646.

LaBeaud AD, Muiruri S, Sutherland LJ, Dahir S, Gildengorin G and Morril J. (2011b). Postepidemic analysis of Rift Valley fever virus transmission in northeastern Kenya: a village cohort study. PLoS. Negl. Trop. Dis, 5, 1265.

Mandel R and Flick R. (2010). Rift Valley fever virus an unrecognized emerging threat?. Human. Vacc, 6, 597-601.

Munyua P, Murithi R, Wainwright S, Githinji J, Hightower A and Mutonga D. (2010). Rift Valley fever outbreak in livestock in Kenya, 2006-2007. Am. J. Trop. Med. Hyg, 83, 58-64.

Murithi R, Munyua P, Ithondeka P, Macharia J, Hightower A and Luman E. (2011). Rift Valley fever in Kenya: the history of epizootics and identification of vulnerable districts. Epidemiol. Infect, 139, 372-80.

Narayanan A, Kehn-Hall K, Senina S, Hill L, van Duyne R and Guendel I. (2012). Curcumin inhibits Rift Valley fever replication in human cells. J. Biol. Chem, 40, 198-214.

Nderitu L, Lee J, Omolo J, Omulo S, O’Guinn M and Hightower A. (2011). Sequential Rift Valley fever outbreaks in Eastern Africa caused by multiple lineages of the virus. J. Infect. Dis, 203, 655-65.

Nguku P, Sharif S, Mutonga D, Amwayi S, Omolo J and Mohammed O. (2010). An investigation of a major outbreak of Rift Valley fever in Kenya: 2006-2007. Am. J. Trop. Med. Hyg, 83, 5-13.

Olive M, Goodman S and Reynes J. (2012). The role of wild mammals in the maintenance of Rift Valley fever virus. J. Wildl. Dis, 48, 241-66.

Pal M. (2007). Zoonoses. 2nd Edn. Satyam Publishers, Jaipur, India.

Pal M, Aklilu N. and Giro B. (2012). Rift Valley fever: A fatal viral disease of neonatal animals. International Journal of Livestock Research 2:14-20.

Palmer S. (2011). Oxford textbook of zoonoses: biology, clinical practice, and public health control (2nd edn.). Oxford University Press.

Paweska J and Jansen van Vuren P. (2013). Rift Valley fever virus: a virus with potential for global emergence. In J. In: N (Ed.), The role of animals in emerging viral diseases .Elsevier, Academic Press. pp. 169-200.

Pepin M, Bouloy M, Bird B, Kemp A and Paweska J. (2010). Rift Valley fever virus (Bunyaviridae: Phlebovirus): an update on pathogenesis, molecular epidemiology, vectors, diagnostics, and prevention. Vet. Res, 41, 61.

Pienaar N and Thompson P. (2013). Temporal and spatial history of Rift Valley fever in South Africa: 1950 to 2011. Onderstepoort. J. Vet. Res, 80, 384.

Poourrut X, Nkoghe D, Souris M, Paupy C, Paweska J and Padilla C. (2010). Rift Valley fever seroprevalence in human rural populations of Gabon. PLoS. Negl.Trop. Dis, 4, 763.

Pratt N, Bonnet P, Jabbar M, Ehui S and deHaan C. (2004). Benefits and Costs of Compliance in Sanitary Regulations in Livestock Markets: The Case of Rift Valley Fever in Ethiopia. Paper presented at the 7th Annual Conference on Global Economic Analysis, Washington DC, 17-19.

Reed C, Lin K, Wilhelmsen C, Friedrich B, Nalca A and Keeney A. (2013). Aerosol exposure to Rift Valley fever virus causes earlier and more severe neuropathology in the murine model, which has important implications for therapeutic development. PLoS. Neg.Trop. Dis, 7, 2156.

Rich K and Perry B. (2011). The economic and poverty impacts of animal diseases in developing countries: new roles, new demands for economics and epidemiology. Prev. Vet. Med, 101, 133-147.

Rich K and Wanyoike F. (2010). An assessment of the regional and national socio-economic impacts of the 2007 Rift Valley fever outbreak in Kenya. Am. J. Trop. Med. Hyg, 83, 52-7.

Scott T, Paweska J, Arbuthnot P and Weinberg M. (2012). Pathogenic effects of Rift Vally fever virus NSs gene are alleviated in cultured cells by expressed antiviral short hairpin RNAs. Antivir. Ther, 17, 643-56.

Seifert SH. (1996). Tropical animal. 2nd Edn. Netherland: Klumer, 247.

Sindato C, Karimuribo E and Mboera L. (2011). The epidemiology and socio-economic impact of rift valley fever epidemics in Tanzania: a review. Tanzan. J. Health. Res, 13, 305-318.

Sindato C, Swai E, Karimuribo E, Dautu G, Pfeiffer D and Mboera L. (2013). Spatial distribution of non-clinical Rift Valley fever viral activity in domestic and wild ruminants in northern Tanzania. Tanzania. Vet. J, 28, 21-38.

Soumare´ B, Thys E, Berkvens D, Hashi A and Van Huylenbroeck G. (2006). Effects of livestock import bans imposed by Saudi Arabia on Somaliland for sanitary reasons related to Rift Valley fever. Outlook. Agric, 35, 19-24.

Sow A, Faye O, Ba Y, Ba H, Diallo D and Faye O. (2014). Rift Valley fever outbreak, Southern Mauritania,2012. Emerg. Infect. Dis, 20, 2012-15.

Swanepoel R and Paweska J. (2011). Rift Valley fever. In S. L. In: Palmer SR (Ed.), Oxford textbook of zoonoses: biology, clinical practice, and public health control. Oxford University Press, pp. 421-31.

Swanepoel, R. (1994). Rift Valley fever. In T. R. JAW Coetzer GR (Ed.), Infectious diseases of livestock with special reference to southern Africa. Cape Town: Oxford University Press. P.688-717.

Tran A, Trevennec C, Lutwama J, Sserugga J, Gely M and Pittiglio C. (2016). Development and assessment of a geographic knowledge-based model for mapping suitable areas for Rift Valley fever transmission in Eastern Africa. PLoS. Negl. Trop. Dis, 10, 9..

WHO (World Health Organization). (2005). International Health Regulations. http://www.who.int/ ihr/en/.

WHO (World Health Organization). (2007). Outbreaks of Rift Valley fever in Kenya, Somalia and United Republic of Tanzania, December 2006- April 2007.

WHO (World Health Organization). (2010). Rift Valley fever. Fact sheet N°207.






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